- The system lends itself easy for testing platelet function for clinical screening, and selection of patients at risk of bleeding or thrombosis diagnostic studies, pharmaceutical research and platelet research studies. Ideal for rapid, easy to use test to monitor anti-thrombotic drug therapies and detect use of anti-platelet drugs and supplements.
- Whole blood Aggregometer represents a major improvement in platelet function testing compared to optical methods using PRP as:
- Extensive preparatory steps and time are not involved
- Platelet behaviour is not modified leading to loss of important sub populations of platelets
- No loss of short half life mediators are involved, which can modify platelet behaviour, such as prostacyclin PGI2 and thromboxane A2.
- Red cells and other components of whole blood, which can affect platelet behaviour, are excluded from the artificial milieu of PRP.
- Whole blood method is both economical and efficient and above all has heightened sensitivity in testing, thereby permitting more easy screening tests for platelet dysfunction with quick turn around time.
- Chrono-log system in the whole blood method is also particularly suited for work with
paediatric patients and smaller laboratory animals, a big advantage.
- Centrifugation step involved in preparing PRP in the optical method results in loss of giant or irregularly shaped platelets, and this problem is eliminated using the impedance technique so that a more representative active platelet population can be studied. This is again a major merit with whole blood method in aggregation.
- The whole blood method is more convenient for detection of platelet hyperaggregability than the optical method. The greater sensitivity results, by performing tests in the presence of erythrocytes and leukocytes.
- Impedance (whole blood) aggregation is very useful in monitoring dose response of platelet inhibitory therapeutic tests. In addition, impedance aggregation is about 100 times more sensitive to the effects of Ticlopidine, than optical aggregation.
- In the case of research, ex-vivo testing and bed-side testing, whole blood aggregation, where no sample preparation steps are involved, is a major advantage, and complete profile can be performed within 35 minutes, after sample collection!!
- Impedance technique can measure aggregation that optical methods cannot, in haemolysed or icteric or lipemic samples, where the sample turbidity interferes with measurement.
- The cost of aggregation profiles is lower almost by 60%, compared to PRP, offering great saving.