Gonotec Gmbh, Germany

OSMOMAT 3000 AUTOMATIC CRYOSCOPIC OSMOMETER

OSMOMAT 3000 AUTOMATIC CRYOSCOPIC OSMOMETER with LCD touch screen, for measurement of osmolality of aqueous solutions from small sample volumes based on the freezing point, the most widely used method.

DESCRIPTION

OSMOMAT 3000 AUTOMATIC CRYOSCOPIC OSMOMETER with LCD touch screen, for measurement of osmolality of aqueous solutions from small sample volumes based on the freezing point, the most widely used method.

MEASUREMENT PRINCIPLE

The total osmolality of aqueous solutions is determined by comparative measurements of the freezing points of pure water and of solutions. Whereas water has a freezing point of 0 °C, a solution with saline concentration of 1 Osmol/kg has a freezing point of -1.858 °C.

MAJOR MERITS

1. LCD touch screen for menu driven easy operation and convenience

2. Stepwise guidance for the users to the entire measurement process and functions.

3. Choice of two or three point calibration to suit specific application requirements

4. QM assistance for the laboratory for ensuring quality results always

5. The results are available, if equipped with optional built in dot matrix printer, in easy document ready format

6. Permits easy data transfer to a P C via USB or RS232 port

7. The last result is available on board, even after machine goes into stand by mode, thereby offering convenience

8. The test result available in less than a minute after machine goes into stand by mode, with quick turn around time

9. Planned purchase with availability of optional accessories like barcode reader, dot matrix printer, measurement for 15µl sample

10. Comprehensive range of calibrators and referral solution available to choose based on specific user applications

DISPLAY LCD

Touch Screen

CRYST. PROCESS

By means of the tip of a stainless steel needle covered with ice crystals which is controlled automatically

COOLING

By means of two separate peltier cooling systems with heat dissipation by air

LOWER COOLING SYSTEM

Electronic temperature regulation, deviation < ±0.1 ºC

SAMPLE VOLUME

50 µl (optional 15µl)

TEST TIME

60 seconds

SAMPLE CAPACITY

Single Sample

UNITS

mOsmol/kg H2O

RESOLUTION

1 mOsmol/kg H2O

RANGE

0 up to 3000 mOsmol/kg H2O

COMMUNICATIONS

DTE RS-232 serial port, USB and barcode scanner port

LINEARITY

Less than ±1% from a straight line between 0 and approx. 3000 mOsmol/kg H2O

REPRODUCIBILITY

≤ ±2 digit [0.. 400] mOsmol/kg H2O
≤ ±0.5% [400.. 1500] mOsmol/kg H2O
≤ ±1.0% [1500.. 3000] mOsmol/kg H2O

AMBIENT TEMPERATURE

10ºC to 35ºC

POWER SUPPLY

100-240V, 50/60Hz, 45VA

DIMENSIONS

220 × 205 × 360 mm

WEIGHT

approx. 6,4 kg

CLINICAL APPLICATIONS

1. The osmometer  finds extensive clinical  applications  including diagnosis of renal activity diseases, electrolyte imbalance, hyper and hyponatremia,  measuring osmolality  of  body fluids, intravenous therapy, blood bank, shock and trauma, nutritional support, paediatric applications and many more.

 2. Osmolality is the fundamental to all physio chemical processes in the body, involving diffusion of solutes and transfer  of  fluids through membranes. Hence, osmolality of various  body fluids has intrinsic value in  the  treatment  and clinical management of patients.

3. Osmolality measurement of serum determines the extent of departure from the narrow range of normality (270 to 290mOsmol/kg) maintained in haemostasis.

4. Abnormal osmolality  of blood  can  be  associated  with   water intoxication anomalies in sodium balance, increased glucose  levels (ketogenic or non ketogenic diabetes) increased urea concentration (renal failure) and burns.

5. Measurement  of  urine  osmolality in  conjunction   with   serum osmolality helps in assessment of renal concentration  capability, and in addition would be an effective way to check effectiveness of diuretic drugs.

6. It is also useful in differential diagnosis of compulsive water intoxication  and diabetes insipidus.

7. Osmolality in addition to usefulness in evaluating concentrating ability, is used to monitor ADH therapy to ascertain renal function.

8 . Measurement  of urine osmolality in many situations is the  method of choice over measurement of specific gravity.

9. The intravenous administration of solutions during treatment  also involves risks of osmolality changes both in  pre and  post operative situation  and  serum osmolality measurements are used to monitor effectively, while treating the patient.

10. Serum osmolality also helps in controlling mannitol administration in  the cerebral  edema.  In fact it is a  good practice to check periodically, the osmolality of salines, hyperalimentation solutions and other infusions before administration, as an abundant precautionary measure.

11. In case of blood banks during thawing of frozen  red  cells,  a number  of washing steps of the cells will be required,  to  reduce the level of glycerol. The osmometer provides clear  and direct measure of residual glycerol content in the cell suspension.

12. Often times, the theoretical calculation of osmolality is resorted to,  using  the formula based on sodium, glucose and urea. The difference  between measured and calculated osmolality is a clear marker for treating acutely ill patients, since it  indicates the high concentration of unidentified solutes in serum.

13.Measurement of osmolality also finds application in assessment of electrolyte content and sweat in the diagnosis of cystic fibrosis. The measurement of osmolality  has  also  been suggested   for screening  of alcohol intoxication, since the concentration of  0.1 l/dl  of alcohol
would increase osmolality by 22mOsmol/kg. This  is significant when compared with 290mOsmol/kg, the normal value.

14. Another  interesting  use  of osmometer is  in  interpretation of electrolyte levels found in extremely hyperlipemic sera.

15. The difference between calculated osmolality and measured osmolality is an indicator for toxicology and trauma. Only the freezing point is not affected due to the presence of alcohol and ketones and offering reliable diagnosis.

16. Osmolality measurement for hydration status for athletes, a very useful application in sports medicine, as weight class and endurance events are precursor to dehydration with performance and health related consequences.

17. Osmometer is a very useful tool to maintain the absorption of irrigation fluids like, glycine ingestion in surgical procedures involved.

18. The measurement of osmolality is the method of choice to differentiate DKA and NKH for providing guidance for effective therapy.

19. Osmometry measurement is useful for drugs screening, for ascertaining sample purity, since low urine osmolality is indicative of tampering!

20. Measurement of effective osmolality is critical in electron microscopy for ensuring proper buffering of fixative solution.

It should be clear from the above and other possible useful applications, that osmometer is an invaluable diagnostic tool in a clinical lab, ICU, ICCU, IVF, blood bank, and several other areas for routine and research applications.

Buyer’s specifications for freezing point osmometer:

1. The machine should be based on the principle of freezing point measurement with a linear measuring range between 0 and 3000mOsmol/kg

2. Shall have LCD touch screen for easy control, convenience in operation and step by step user guidance

3. (a) The nominal sample volume should be 50l, and with provision to use 15ml as minimum volume
(b) The measurement should be completed within a minute for handling higher workloads and serial measurements

4.(a) The osmometer shall have facility for selection of two or three point calibration as preferred
(b) Provision should exist for automatic calibration using manufacturer’s standards, and easy to perform, and calibration should be stable for a long period

5. The sample cooling shall be with high capacity air cooled peltier, without need for cooling liquid for dissipation of heat, or involving maintenance

6. Shall have automation with (i) the initiation of the crystallisation, (ii) detection of the measuring value, (iii) storage and (iv) calibration for reproducible results

7.(a) The resolution of the measurement should be one mOsmol/kg or better, over the entire range of measurement
(b) The reproducibility should be within 2mOsmol/kg or better, and applicable over the range of 0 to 400 mOsmol/kg, and at least 4 mOsmol/kg in range of 400 to 3000 mOsmol/kg

8. Quality management assistance shall be available for compliance with regulations

9. Should have provision for optional built-in printer, graphic, non thermal type, dot matrix with date, time and sample data

10. Should have facility for optional bar-code reader, with ability for collection of sample data, via bar code reader, when equipped with

11. Shall be offered with dedicated external quality control software for freezing point osmometer, covering calibration, control and result validation with Levy Jennings plot and chartable report format with full audit trail

There shall be price indications for (i) consumables to run 1000 samples including sample cups, calibrators, controls, printer paper, and cleaning agent (ii) recommended maintenance kit with value not exceeding 7.5% of the cost of the machine, for trouble free operation (iii) suitable stabiliser

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